SAP130 Products

Description

SAP130 encodes subunit 3 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 3 has also been identified as a component of the STAGA (SPT3-TAF(II)31-GCN5L acetylase) transcription coactivator-HAT (histone acetyltransferase) complex, and the TFTC (TATA-binding-protein-free TAF(II)-containing complex). These complexes may function in chromatin modification, transcription, splicing, and DNA repair.

Bioinformatics

Entrez	101943 Mouse 23450 Human
Uniprot	NM_012426 Human NP_036558 Human NP_036558.3 Human NP_078821 Human Q15393 Human Q9H0E3 Human
Product By Gene ID	23450
Alternate Names	KIAA0017splicing factor 3b, subunit 3, 130kD Pre-mRNA-splicing factor SF3b 130 kDa subunit RSE1 SAP130SAP 130 SF3B130 SF3b130pre-mRNA splicing factor SF3b, 130 kDa subunit Spliceosome-associated protein 130 splicing factor 3B subunit 3 splicing factor 3b, subunit 3, 130kDa STAF130