SAM68 Products

Description

Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain-containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA nuclear export Function: Isoform 3, which is expressed in growth-arrested cells only, inhibits S phase

Bioinformatics

Entrez	10657 Human
Uniprot	AAH00717 Human AAH10132 Human AAH10132.1 Human NP_006550 Human Q07666 Human
Product By Gene ID	10657
Alternate Names	FLJ34027 GAP-associated tyrosine phosphoprotein p62 KH domain containing, RNA binding, signal transduction associated 1 KH domain-containing, RNA-binding, signal transduction-associated protein 1 p21 Ras GTPase-activating protein-associated p62 p62 p68 SAM68 Sam68GAP-associated tyrosine phosphoprotein p62 (Sam68) Src-associated in mitosis 68 kDa protein