Species: Mu
Applications: WB, IHC
Host: Goat Polyclonal
Species: Hu, Mu, Rt
Applications: WB, ELISA, ICC/IF, IHC
Host: Rabbit Polyclonal
Species: Hu, Mu
Applications: WB
Host: Mouse Monoclonal
Species: Hu
Applications: ELISA
Species: Hu
Applications: WB
Species: Mu
Applications: Bioactivity
Species: Hu
Applications: Bioactivity
Species: Mu
Applications: Bioactivity
Description
R-spondin1, also known as RSPO1, CRISTIN3, FLJ40906. Entrez Protein NP_001033722.1. It is a member of the R-spondin family and a 28.9kDa secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects.It is activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway, possibly via a direct interaction with Wnt proteins, and in a Wnt-independent beta catenin pathway through a receptor signaling pathway that may not use frizzled/LRP receptors. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination.
Bioinformatics
| Entrez |
Human
|
| Uniprot |
Human
Human
|
| Product By Gene ID |
284654 |
| Alternate Names |
- CRISTIN3
- FLJ40906Roof plate-specific spondin-1
- hRspo1
- roof plate-specific spondin
- RSPO
- R-spondin homolog (Xenopus laevis)
- RSPONDIN
- R-spondin1
- R-spondin-1
|
![N/A R-Spondin 1 [Biotin]](http://images.novusbio.com/fullsize2/DATA_RSpondin_1_DY464505_ELISA_2464.jpg)
![Bioactivity R-Spondin 1 [Unconjugated]](http://images.novusbio.com/fullsize/protein/7150-rs_recombinant-mouse-r-spondin-1-cho-expressed-protein-bioactivity-272020133950.jpg)
![Bioactivity R-Spondin 1 [Unconjugated]](http://images.novusbio.com/fullsize2/RSpondin_1_4645RS_1221.jpg)
![Bioactivity R-Spondin 1 [Unconjugated]](http://images.novusbio.com/fullsize2/4645-rs_recombinant-human-r-spondin-1-protein-322023104349.jpg)
![SDS-PAGE R-Spondin 1 [Unconjugated]](http://images.novusbio.com/fullsize2/R-Spondin_1_4645-RS_240.jpg)
![Bioactivity R-Spondin 1 [Unconjugated]](http://images.novusbio.com/fullsize/4645-rs_recombinant-human-r-spondin-1-protein-bioactivity-252023101150..jpg)
![Bioactivity R-Spondin 1 [Unconjugated]](http://images.novusbio.com/fullsize/4645-rs_recombinant-human-r-spondin-1-protein-bioactivity-25202310142..jpg)
![Bioactivity R-Spondin 1 [Unconjugated]](http://images.novusbio.com/fullsize2/R-Spondin_1_3474-RS_361.jpg)
![SDS-PAGE R-Spondin 1 [Unconjugated]](http://images.novusbio.com/fullsize2/R-Spondin_1_3474-RS_360.jpg)