PTP pi/PTPRU Products

Description

The protein encoded by the PTPRU gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. This PTP was thought to play roles in cell-cell recognition and adhesion. Studies of the similar gene in mice suggested the role of this PTP in early neural development. The expression of this gene was reported to be regulated by phorbol myristate acetate (PMA) or calcium ionophore in Jurkat T lymphoma cells. Three alternatively spliced transcript variants, which encode distinct proteins, have been reported. (provided by RefSeq)

Bioinformatics

Entrez	10076 Human
Product By Gene ID	10076
Alternate Names	FMI hPTP-J pancreatic carcinoma phosphatase 2 PCP2 PCP-2 pi R-PTP-Psi protein tyrosine phosphatase J protein tyrosine phosphatase, receptor type, U protein-tyrosine phosphatase J protein-tyrosine phosphatase pi PTP pi PTP PTP-J PTP-PI PTPPSI PTP-RO Receptor protein tyrosine phosphatase hPTP-J R-PTP-PSI