PrPC Products

Description

Prion diseases are transmissible neurodegenerative disorders which affect a range of mammalian species. In humans they can be inherited and sporadic as well as acquired by exposure to human prions. Prions appear to be composed principally of a conformational isomer of host-encoded prion protein and propagate by recruitment of cellular prion protein (1). The function of the cellular prion protein (PrP) is still poorly understood. It has been proposed that one unprecedented role for PrP is against Bax-mediated neuronal apoptosis. It has been shown that PrP potently inhibits Bax-induced cell death in human primary neurons (2). An impaired synaptic inhibition may be involved in the epileptiform activity seen in Creutzfeldt-Jakob and other neurodegenerative diseases and it is believed that loss of function of PrP may contribute to the early synaptic loss and neuronal degeneration seen in these diseases (3).

Bioinformatics

Entrez	19122 Mouse 24686 Rat 493887 Sheep 5621 Human
Uniprot	AAH12844 Human ENSP00000368752 Human NM_183079 Human NP_000302.1 Human P04156 Human P04156 Human
Product By Gene ID	5621
Alternate Names	CD230 CJD fatal familial insomnia) GSS prion protein (p27-30) prion protein PrP prion protein prion-related protein PRIPMGC26679

Research Areas for PrPC

Find related products by research area and learn more about each of the different research areas below.

Neuroscience
Stem Cell Markers