PLK1 Products

Description

Considerable evidence indicates that a Polo-Like Kinase (PLK) plays an important role in cell cycle regulation. PLK is also required for bipolar spindle formation, activation of the anaphase-promoting complex/cyclosome, and cytokinesis. Recent work led to the identification of a PLKK that is thought to be responsible for activation of PLK. Recent work (Erikson, et al., 2004) has shown that PLKK is in turn activated by phosphorylation at three sites (Ser482, Ser486 and Ser490). Thus activation of PLK is thought to involve a kinase cascade involving the phosphorylation of Ser482,486,490 in PLKK.

Bioinformatics

Entrez	18817 Mouse 25515 Rat 5347 Human
Uniprot	AAH02369 Human NM_005030 Human NP_005021 Human NP_005021.2 Human P53350 Human
Product By Gene ID	5347
Alternate Names	cell cycle regulated protein kinase EC 2.7.11 EC 2.7.11.21 PLK PLK-1 polo (Drosophia)-like kinase polo like kinase polo-like kinase 1polo-like kinase (Drosophila) Serine/threonine-protein kinase 13 serine/threonine-protein kinase PLK1 STPK13

Research Areas for PLK1

Find related products by research area and learn more about each of the different research areas below.

Breast Cancer
Cancer
Cell Cycle and Replication
Checkpoint signaling
Core ESC-Like Genes
DNA Double Strand Break Repair
DNA Repair
Mitotic Regulators
Phospho-Specific
Stem Cell Markers