Description
PDGFC, also known as Platelet-derived growth factor C, has 3 isoforms, a 345 amino acid isoform that is 39 kDa, a 282 amino acid isoform that is 32 kDa and a 167 amino acid isoform that is 19 kDa, expressed in the fallopian tube, vascular smooth muscle cells in kidney, breast and colon and in visceral smooth muscle of the gastrointestinal tract and retinal pigment epithelia; plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis, wound healing, represents potent mitogen for cells of mesenchymal origin, induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis, can initiate events that lead to a mesangial proliferative glomerulonephritis, including influx of monocytes and macrophages and production of extracellular matrix. This protein is being studied for its involvement in mesangial proliferative glomerulonephritis, proliferative glomerulonephritis, glomerulonephritis, brain cancer, prostate carcinoma, nephropathy, prostatitis, prostate cancer, atherosclerosis, retinitis, melanoma, and carcinoma. The protein has been linked to the cytoskeleton remodeling role of PDGFs in cell migration, development PDGF signaling via MAPK cascades, release of novel PDGFs as latent factors, signal transduction, signaling by PD, focal adhesion, gap junction, regulation of actin cytoskeleton, prostate cancer, and melanoma GF pathways where it interacts with PDGFRB, PDGFRA, PLAT, PLAU, PLAUR, EGFR, ERBB2, FGFR1, FLT1, and FLT4 proteins.
Bioinformatics
| Uniprot |
Human
Human
Human
Mouse
Human
|
| Product By Gene ID |
56034 |
| Alternate Names |
- fallotein
- Fallotein
- FALLOTEIN
- PDGF-C
- platelet derived growth factor C
- platelet-derived growth factor C
- SCDGFSpinal cord-derived growth factor
- secretory growth factor-like protein
- VEGF-E
|
![Immunohistochemistry PDGF-C Antibody [Unconjugated]](http://images.novusbio.com/fullsize2/af1447_mouse-pdgf-c-affinity-purified-polyclonal-ab-immunohistochemistry-1052021161332.jpg)
![Neutralization PDGF-C Antibody [Unconjugated]](http://images.novusbio.com/fullsize2/PDGF-C_AF1447_Block_Neutralize_8780.jpg)
![Immunocytochemistry/ Immunofluorescence PDGF-C Antibody [Unconjugated]](http://images.novusbio.com/fullsize/af1447_mouse-pdgf-c-affinity-purified-polyclonal-ab-822024950327.jpg)
![Immunocytochemistry/ Immunofluorescence PDGF-C Antibody [Unconjugated]](http://images.novusbio.com/fullsize/af1447_mouse-pdgf-c-affinity-purified-polyclonal-ab-44202415425060.jpg)
