ORC1 Products

Description

The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is the largest subunit of the ORC complex. While other ORC subunits are stable throughout the cell cycle, the levels of this protein vary during the cell cycle, which has been shown to be controlled by ubiquitin-mediated proteolysis after initiation of DNA replication. This protein is found to be selectively phosphorylated during mitosis. It is also reported to interact with MYST histone acetyltransferase 2 (MyST2/HBO1), a protein involved in control of transcription silencing. [provided by RefSeq]

Bioinformatics

Uniprot	AAH11539 Human NP_004144 Human NP_004144.2 Human Q13415 Human
Product By Gene ID	4998
Alternate Names	HS HSORC1 ORC1Lorigin recognition complex subunit 1 origin recognition complex, subunit 1 (yeast homolog)-like origin recognition complex, subunit 1 homolog (S. cerevisiae) origin recognition complex, subunit 1 homolog origin recognition complex, subunit 1 origin recognition complex, subunit 1-like (yeast) origin recognition complex, subunit 1-like PARC1origin recognition complex 1 Replication control protein 1

Research Areas for ORC1

Find related products by research area and learn more about each of the different research areas below.

Cancer
Core ESC-Like Genes
DNA Repair
Stem Cell Markers