OAS2 Products

Description

OAS2 encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq]

Bioinformatics

Uniprot	NM_002535 Human NP_002526.2 Human P29728 Human P29728-2 Human
Product By Gene ID	4939
Alternate Names	(2-5')oligo(A) synthase 2 (2'-5')oligo(A) synthetase 2 (2-5')oligo(A) synthetase 2 2'5' oligoadenylate synthetase 2 2-5A synthase 2 2-5A synthetase 2 2'-5'-oligoadenylate synthase 2 2'-5'-oligoadenylate synthetase 2 (69-71 kD) 2'-5'-oligoadenylate synthetase 2, 69/71kDa EC 2.7.7 EC 2.7.7.- MGC78578 p69 OAS / p71 OAS p69OAS / p71OAS

Related OAS2 Blog Posts

Check out the latest blog posts on OAS2.

COVID-19 and metabolic dysregulation: SARS-CoV-2 injures human exocrine and endocrine pancreas Jamshed Arslan, Pharm D, PhD Humans rely on the pancreas for digesting food and generating energy from it. SARS-CoV-2-mediated damage to the exocrine pancreas is evident from the pancreatitis, pancreatic enlargeme...    Read more.

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