NGFRAP1/BEX3/NADE Products

Description

The p75 neurotrophin receptor (p75NTR) is a member of the tumor necrosis receptor superfamily and can mediate cell death and cell survival in response to nerve growth factor (NGF). The p75NTR-associated cell death executor (NADE) mediates apoptosis by interacting with the cell death domain of p75NTR following the binding of NGF by p75NTR. Recent studies have shown that NADE also interacts with second mitochondria-derived activator of caspase (Smac). Coexpression of NADE and Smac promotes TRAIL-induced apoptosis and inhibits XIAP-mediated Smac ubiquitization. It has been suggested that it is this interaction between NADE and Smac that allows apoptosis to proceed. Finally, although initially discovered as an mRNA expressed in ovarian granulosa cells, NADE has been suggested to play a role in the neuronal death seen in epileptic brain damage.

Bioinformatics

Uniprot	AAH03190 Human NP_055195 Human NP_996798 Human NP_996800 Human NP_996800.1 Human
Product By Gene ID	27018
Alternate Names	BEX3p75NTR-associated cell death executor Brain-expressed X-linked protein 3 DXS6984EX-linked 3 HGR74 nerve growth factor receptor (TNFRSF16) associated protein 1 Nerve growth factor receptor-associated protein 1 Ovarian granulosa cell 13.0 kDa protein HGR74 ovarian granulosa cell protein (13kD) protein BEX3

Research Areas for NGFRAP1/BEX3/NADE

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Apoptosis