NAPE-PLD Products

Description

NAPE-PLD (also known as N-Acylphosphatidylethanolamine (NAPE)-hydrolyzing phospholipase D) is a membrane-bound phospholipase D type enzyme that catalyzes the release of N-acylethanolamine (NAE) from N-acyl-phosphatidylethanolamine (NAPE) in the second step of the biosynthesis of N-acylethanolamine. NAPE-PLD has been shown to be expressed by specific populations of neurons in the brain and targeted to axonal processes. Recent studies have suggested that NAEs generated by NAPE-PLD in axons may act as anterograde synaptic signaling molecules that regulate the activity of postsynaptic neurons. NAPE-PLD has also been shown to catalyze the hydrolysis of NAPE to generate OEA (oleoylethanolamide), a natural lipid amide that inhibits food intake in free-feeding rodents by prolonging latency to feed and postmeal interval.

Bioinformatics

Uniprot	NM_198990 Human NP_001116310 Human Q6IQ20 Human Q8BH82 Mouse
Product By Gene ID	222236
Alternate Names	C7orf18 DKFZp781D1098 EC 3.1.4 EC 3.1.4.- N-acyl phosphatidylethanolamine phospholipase DNAPE-PLDFMP30 N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D NAPE-hydrolyzing phospholipase D

Research Areas for NAPE-PLD

Find related products by research area and learn more about each of the different research areas below.

Lipid and Metabolism
Signal Transduction