MYO3A Products

Description

MYO3A is encoded by this gene belongs to the myosin superfamily. Myosins are actin-dependent motor proteins and are categorized into conventional myosins (class II) and unconventional myosins (classes I and III through XV) based on their variable C-terminal cargo-binding domains. Class III myosins, such as this one, have a kinase domain N-terminal to the conserved N-terminal motor domains and are expressed in photoreceptors. The protein encoded by this gene plays an important role in hearing in humans. Three different recessive, loss of function mutations in the encoded protein have been shown to cause nonsyndromic progressive hearing loss. Expression of this gene is highly restricted, with the strongest expression in retina and cochlea.

Bioinformatics

Uniprot	AAH45538.1 Human NP_059129 Human
Product By Gene ID	53904
Alternate Names	deafness, autosomal recessive 30 DFNB30 EC 2.7.11 EC 2.7.11.1 myosin IIIA myosin-IIIa

Research Areas for MYO3A

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Protein Kinase
Vision