MuSK Products

Description

Intercellular communication is often mediated by receptors on the surface of one cell that recognize and are activated by specific protein ligands released by other cells. Members of one class of cell surface receptors, receptor tyrosine kinases (RTKs), are characterized by having a cytoplasmic domain containing intrinsic tyrosine kinase activity. This kinase activity is regulated by the binding of a cognate ligand to the extracellular portion of the receptor. DeChiara et al. (1996) [PubMed 8653786] noted that the RTKs, known to be expressed in cell type-specific fashions, play a role critical for the growth and differentiation of those cell types. For example, members of the neural-specific TRK family that recognize nerve growth factor are absolutely required for the survival and development of discrete neuronal subpopulations, and the receptor tyrosine kinases TIE1 (MIM 600222) and TIE2 (MIM 600221) play a critical role in the development of normal blood vessels.[supplied by OMIM]

Bioinformatics

Uniprot	NM_005592 Human NP_005583 Human O15146 Human
Product By Gene ID	4593
Alternate Names	EC 2.7.10 EC 2.7.10.1 MGC126323 MGC126324 muscle, skeletal, receptor tyrosine kinase MuSK skeletal receptor tyrosine-protein kinase

Research Areas for MuSK

Find related products by research area and learn more about each of the different research areas below.

Protein Kinase
Signal Transduction