MTHFD1 Products

Description

MTHFD1 encodes a protein that possesses three distinct enzymatic activities, 5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methenyltetrahydrofolate cyclohydrolase and 10-formyltetrahydrofolate synthetase. Each of these activities catalyzes one of three sequential reactions in the interconversion of 1-carbon derivatives of tetrahydrofolate, which are substrates for methionine, thymidylate, and de novo purine syntheses. The trifunctional enzymatic activities are conferred by two major domains, an aminoterminal portion containing the dehydrogenase and cyclohydrolase activities and a larger synthetase domain. [provided by RefSeq]

Bioinformatics

Entrez	108156 Mouse 4522 Human 64300 Rat
Uniprot	AAH09806 Human AAH50420.1 Human NP_005947 Human P11586 Human
Product By Gene ID	4522
Alternate Names	C1-THF synthase EC 6.3.4.3 methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methylenetetrahydrofolatecyclohydrolase, 10-formyltetrahydrofolate synthetase methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 MTHFCC-1-tetrahydrofolate synthase, cytoplasmic MTHFDcytoplasmic C-1-tetrahydrofolate synthase

Research Areas for MTHFD1

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Stem Cell Markers