MST4 Products

Description

Novel human Ste20-related kinase Mst4 is highly expressed in placenta, thymus, and peripheral blood leukocytes. Mst4 is biologically active in the activation of MEK/ERK pathway and in mediating cell growth and transformation (1). Wild type and C-terminally truncated forms of Mst4 can both induce apoptosis upon overexpression in mammalian cells that is abrogated by CrmA, suggesting involvement of Mst4 in the apoptotic machinery in mammalian cells (2). Mst4 was found to be expressed in prostate carcinoma tumor samples and cell lines. In addition, expression levels appeared to correlate with tumorigenicity and androgen receptor status of the cells. Mst4 kinase activity was stimulated significantly by epidermal growth factor receptor ligands, which are known to promote growth of prostate cancer cells (3).

Bioinformatics

Entrez	51765 Human
Uniprot	NM_016542 Human NP_057626 Human NP_057626.2 Human
Product By Gene ID	51765
Alternate Names	EC 2.7.11 EC 2.7.11.1 Mammalian STE20-like protein kinase 4 mammalian sterile 20-like 4 MASK Mst3 and SOK1-related kinase MST-4 serine/threonine protein kinase MASK serine/threonine protein kinase MST4 Serine/threonine-protein kinase MASK serine/threonine-protein kinase MST4 STE20-like kinase MST4

Research Areas for MST4

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Protein Kinase