MRCL3 Products

Description

The muscle myosins and hexomeric proteins consisting of two heavy chains and two pairs of light chains, the latter called essential (ELC) and regulatory (RLC). The light chains stabilize the long alpha helical neck of the myosin head (1). Human myosin light chain-2 (MYL2) is an important protein involved in the regulation of myosin ATPase activity in smooth muscle. In cardiac muscle, the precise role of MYL2 is not well understood; however, an increase in ventricular MYL2 is observed during myocardial hypertrophy in cardiac patients with valve stenosis (2). Familial hypertrophic cardiomyopathy (FHC) is an autosomal dominant disease caused by mutations in all of the major sarcomeric proteins, including the ventricular myosin regulatory light-chain (RLC). The Myosin RLC mutation has been associated with a rare variant of cardiac hypertrophy defined by mid-left ventricular obstruction due to papillary muscle hypertrophy. This mutation was later found to cause ventricular and septal hypertrophy (3).

Bioinformatics

Entrez	10627 Human
Uniprot	NM_006471 Human NP_006462 Human P19105 Human
Product By Gene ID	10627
Alternate Names	MLCBMyosin RLC MRCL3 MRLC3MLC-2B MYL2B myosin regulatory light chain 12A Myosin regulatory light chain 2, nonsarcomeric myosin regulatory light chain 3 myosin regulatory light chain MRCL3 Myosin regulatory light chain MRLC3 myosin, light chain 12A, regulatory, non-sarcomeric myosin, light polypeptide, regulatory, non-sarcomeric (20kD) RLC