Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC
Host: Rabbit Monoclonal
Species: Hu
Applications: CyTOF-ready, Flow
Host: Mouse Monoclonal
Species: Hu, Mu
Applications: WB, ICC/IF, IHC
Host: Mouse Monoclonal
Species: Mu
Applications: ELISA
Species: Hu
Applications: ELISA
Species: Rt
Applications: ELISA
Species: Hu
Applications: AC
Description
The matrix metalloproteinases are a tightly regulated family of enzymes that degrade extracellular matrix and basement membrane components. Recent evidence suggests that these proteases and their specific inhibitors play important roles in normal developmental processes and in pathological conditions (1). MMP-11 (stromelysin-3), a new member of the matrix metalloproteinase family, is expressed in tissues undergoing the active remodeling associated with embryonic development, wound healing and tumor invasion. But like all other members of the matrix metalloproteinase gene family, stromelysin-3 is synthesized as an inactive precursor that must be processed to its mature form in order to express enzymic activity (2). MMP-11, like an inflammatory mediator, may exert a chemotactic influence on macrophages which aggregate in the mesangium; MMP-11 is not likely to have a parallel mitogenic or antifibrotic effect in diseased glomeruli (3).
Bioinformatics
| Entrez |
Mouse
Rat
Human
|
| Uniprot |
Human
Human
Human
|
| Product By Gene ID |
4320 |
| Alternate Names |
- EC 3.4.24
- EC 3.4.24.-
- EC 3.4.24.24
- matrix metallopeptidase 11 (stromelysin 3)
- matrix metalloproteinase 11 (stromelysin 3)
- Matrix metalloproteinase-11
- MMP-11
- SL-3
- ST3
- STMY3stromelysin 3
- stromelysin III
- stromelysin-3
|
