Species: Hu, Mu, Rt, Ca
Applications: WB, Flow, ICC/IF, IHC, IP
Host: Mouse Monoclonal
Species: Hu, Mu, Rt
Applications: WB, ICC/IF
Host: Rabbit Monoclonal
Species: Hu, Mu, Rt
Applications: WB, IHC
Host: Rabbit Monoclonal
Species: Hu
Applications: WB
Species: Hu
Applications: AC
Description
MKK4, also known as JNKK1 and SEK1, is a dual specificity kinase that belongs to the Ser/Thr protein kinase family. MKK4 is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. MKK4 phosphorylates and activates p38 MAP kinase and JNK but not ERK 1/2 (1-2). JNK is activated by dual phosphorylation at Thr and Tyr by MKK4 and MKK7; although MKK4 will preferentially phosphorylate Tyr (3). MKK4 is also known to be a tumor suppressor, as mutations inactivating the MKK4 gene have been found in 5% of a wide variety of tumor types (4).
Bioinformatics
| Entrez |
Mouse
Rat
Human
|
| Uniprot |
Human
Human
Human
Human
Human
|
| Product By Gene ID |
6416 |
| Alternate Names |
- c-Jun N-terminal kinase kinase 1
- dual specificity mitogen-activated protein kinase kinase 4
- JNK activating kinase 1
- JNK-activated kinase 1
- JNK-activating kinase 1
- JNKK
- JNKK1MAPK/ERK kinase 4
- MAP kinase kinase 4
- MAPKK4
- MEK4MEK 4
- mitogen-activated protein kinase kinase 4
- MKK4SAPK/ERK kinase 1
- PRKMK4MAPKK 4
- SEK1
- SERK1EC 2.7.12.2
|
