Species: Hu
Applications: WB, IHC, IP
Host: Rabbit Polyclonal
Species: Hu
Applications: WB, IHC, KO
Host: Mouse Monoclonal
Species: Hu
Applications: WB, ICC/IF, IHC
Host: Mouse Monoclonal
Species: Hu
Applications: ELISA
Species: Hu
Applications: ELISA
Species: Hu
Applications: WB
Species: Hu
Applications: AC
Species: Hu
Applications: PAGE, SPR
Description
Mcl-1 (Myeloid cell leukemia-1) is Bcl-2-related and was identified as an early-induction gene that increased in expression during the differentiation of human myeloblastic leukemia cell ML-1, or exposure to different DNA damaging agents. The level of Mcl-1 is decreased in peripheral B lymphocytes undergoing apoptosis following treatment with apoptotic stimuli such as TGF-alpha 1 and forskolin. Expression of Mcl-1 is able to delay apoptosis induced by over-expression of c-myc in CHO 5AHSmyc cells. In hematopoietic FDC-P1 cells, Mcl-1 interacts with another Bcl-2-related protein, Bax, and prolongs cell viability after treatment with different apoptotic reagents.This monoclonal antibody detected a 37kd MCL1 in BCBL-1 cell lysate.
Bioinformatics
| Entrez |
Human
|
| Product By Gene ID |
4170 |
| Alternate Names |
- Bcl2-L-3
- bcl2-L-3
- BCL2L3MGC104264
- Bcl-2-like protein 3
- Bcl-2-related protein EAT/mcl1
- EAT
- induced myeloid leukemia cell differentiation protein Mcl-1
- Mcl-1
- mcl1/EAT
- MCL1-ES
- MCL1L
- MCL1S
- MGC1839
- myeloid cell leukemia ES
- myeloid cell leukemia sequence 1 (BCL2-related)
- TM
|
![Western Blot Mcl-1 Antibody (542808) [Unconjugated]](http://images.novusbio.com/fullsize2/Mcl-1_MAB828_Western_Blot_6290.jpg)
![Knockout Validated Mcl-1 Antibody (542808) [Unconjugated]](http://images.novusbio.com/fullsize2/Mcl1_MAB828_Knockout_Validated_22995.jpg)
