MBTPS1 Products

Description

The encoded protein has a central role in the regulation of lipid metabolism in cells. It is a sterol-regulated subtilisin-like serine protease that cleaves ER membrane-bound sterol regulatory element-binding proteins (SREBPs), a reaction that initiates the two-step proteolytic process by which transcriptionally active fragments of SREBPs are released from the membrane for translocation to the nucleus. The gene product is an integral membrane ER protein, with the bulk located in the ER lumen. It is synthesized as an inactive preproprotein that is self-activated by an intramolecular cleavage that generates the mature protein. [provided by RefSeq]

Bioinformatics

Entrez	8720 Human
Uniprot	NM_003791 Human
Product By Gene ID	8720
Alternate Names	EC 3.4.21.112 Endopeptidase S1P KIAA0091MGC138712 membrane-bound transcription factor peptidase, site 1 membrane-bound transcription factor protease, site 1 PCSK8 S1PMGC138711 site-1 protease SKI1 SKI-1membrane-bound transcription factor site-1 protease subtilisin/kexin isozyme-1 Subtilisin/kexin-isozyme 1