LMP2/PSMB9 Products

Description

Proteolytic degradation is critical to the maintenance of appropriate levels of short-lived and regulatory proteins as important and diverse as those involved in cellular metabolism, heat shock and stress response, antigen presentation, modulation of cell surface receptors and ion channels, cell cycle regulation, transcription, and signalling factors. The ubiquitin-proteasome pathway deconstructs most proteins in the eukaryotic cell cytosol and nucleus. Other proteins are degraded via the vacuolar pathway which includes endosomes, lysosomes, and the endoplasmic reticulum. The 26S proteasome is an ATP-dependent, multisubunit (~31), barrel-shaped molecular machine with an apparent molecular weight of ~2.5 MDa. It consists of a 20S proteolytic core complex which is crowned at one or both ends by 19S regulatory subunit complexes. The 19S regulatory subunits recognize ubiquitinated proteins and play an essential role in unfolding and translocating targets into the lumen of the 20S subunit. The PA28/11S REG Activator protein complex functions as a proteolytic activator. LMP2 is a catalytic subunit of the 20S proteasome and, upon interferon gamma-induction, replaces the delta subunit. LMP2 alters the specificity of the 20S proteasome and is critical for the production of MHC class I ligands, production of T-lymphocytes, and is suggested to increase the efficiency of antigen presentation of the immune response. Several genetic diseases are associated with defects in the ubiquitin-proteasome pathway. Some examples of affected proteins include those linked to cystic fibrosis (CF transmembrane regulator), Angelman's syndrome (E6-AP), and Liddle syndrome (endothelial sodium channels).

Bioinformatics

Entrez	16912 Mouse 24967 Rat 5698 Human
Uniprot	AAH65513 Human NM_002800 Human NP_002791 Human NP_002791.1 Human P28065 Human
Product By Gene ID	5698
Alternate Names	beta1i LMP2MGC70470 Low molecular mass protein 2 Macropain chain 7 Multicatalytic endopeptidase complex chain 7 proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctionalpeptidase 2) proteasome catalytic subunit 1i Proteasome chain 7 proteasome subunit beta 6i proteasome subunit beta type-9 Proteasome subunit beta-1i proteasome-related gene 2 PSMB6iproteasome (prosome, macropain) subunit, beta type, 9 (large multifunctionalprotease 2) Really interesting new gene 12 protein RING12EC 3.4.25.1