LATS2 Products

Description

LATS2 encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression.

Bioinformatics

Entrez	26524 Human
Uniprot	NM_014572 Human NP_055387 Human Q9NRM7 Human
Product By Gene ID	26524
Alternate Names	EC 2.7.11 EC 2.7.11.1 FLJ13161 Kinase phosphorylated during mitosis protein KPM Large tumor suppressor homolog 2 LATS (large tumor suppressor, Drosophila) homolog 2 LATS, large tumor suppressor, homolog 2 (Drosophila) serine/threonine kinase KPM Serine/threonine-protein kinase kpm serine/threonine-protein kinase LATS2 Warts-like kinase

Research Areas for LATS2

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Cell Cycle and Replication
GPCR
Phospho-Specific
Tumor Suppressors