LAT Products

Description

LAT (linker for activation of T-cells) is involved in the T-cell antigen receptor (TCR) signal transduction pathway, and may play an important role downstream in activating protein tyrosine kinases (1). LAT is phosphorylated by ZAP-70/Syk protein tyrosine kinases leading to recruitment of multiple signaling molecules (2). It has been found that Tyr191 and Tyr171 are required for T-cell activation and Tyr132 is required for the activation of PLCgamma1 and Ras signaling pathways, respectively. Tyr226 and Tyr191 are required for Vav binding, whereas Tyr171 and Tyr132 are necessary for association and activation of phosphoinositide 3-kinase activity and PLCgamma1 (3).

Bioinformatics

Entrez	16797 Mouse 27040 Human 81511 Rat
Uniprot	AAH11563 Human NP_001014987 Human NP_055202. Human NP_055202.1 Human O43561 Human
Product By Gene ID	27040
Alternate Names	36 kDa phospho-tyrosine adapter protein LAT1,36 kDa phospho-tyrosine adaptor protein linker for activation of T cells linker for activation of T-cells family member 1 p36-38 pp36

Research Areas for LAT

Find related products by research area and learn more about each of the different research areas below.

Adaptive Immunity
Immunology
Phospho-Specific
Signal Transduction

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