KAT4/TBP Associated Factor 1 Products

Description

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is the basal transcription factor TFIID, which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes the largest subunit of TFIID. This subunit binds to core promoter sequences encompassing the transcription start site. It also binds to activators and other transcriptional regulators, and these interactions affect the rate of transcription initiation. This subunit contains two independent protein kinase domains at the N and C-terminals, but also possesses acetyltransferase activity and can act as a ubiquitin-activating/conjugating enzyme. Two transcripts encoding different isoforms have been identified for this gene.

Bioinformatics

Entrez	6872 Human
Uniprot	NP_004597 Human P21675 Human
Product By Gene ID	6872
Alternate Names	250kDa BA2Rdystonia 3 (with Parkinsonism) CCG1TATA box binding protein (TBP)-associated factor, RNA polymerase II, A, 250kD CCGS Cell cycle gene 1 protein cell cycle, G1 phase defect complementation of cell cycle block, G1-to-S DYT3/TAF1 EC 2.7.11 EC 2.7.11.1 KAT4 NSCL2 OF P250 p250 TAF(II)250 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor TAF2AN-TAF1 TAFII-250 TAFII250DYT3 TBP-associated factor 250 kDa transcription factor TFIID p250 polypeptide Transcription initiation factor TFIID 250 kDa subunit transcription initiation factor TFIID subunit 1 XDP

Research Areas for KAT4/TBP Associated Factor 1

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Protein Kinase