Indian Hedgehog/Ihh Products

Description

Hedgehog, WNT, FGF and BMP signaling pathways network together during embryogenesis, tissue regeneration, and carcinogenesis. Aberrant activation of Hedgehog signaling pathway leads to pathological consequences in a variety of human tumors, such as gastric cancer and pancreatic cancer (1). The hedgehog family of morphogens are regulators of cell proliferation, differentiation and cell-cell communication. These morphogens have been shown to have important roles in organogenesis, spermatogenesis, stem cell maintenance and oncogenesis. Indian hedgehog (IHH) has been shown to be expressed in the uterine epithelium under the control of the steroid hormone, progesterone (2). It has been shown that IHH, synthesized by prehypertrophic and hypertrophic chondrocytes, regulates the site of hypertrophic differentiation by signaling to the periarticular growth plate and also determines the site of bone collar formation in the adjacent perichondrium. By providing crucial local signals from prehypertrophic and hypertrophic chondrocytes to both chondrocytes and preosteoblasts, IHH couples chondrogenesis to osteogenesis in endochondral bone development (3).

Bioinformatics

Entrez	16147 Mouse 3549 Human 84399 Rat
Uniprot	AAH34757 Human NP_002172 Human Q14623 Human
Product By Gene ID	3549
Alternate Names	BDA1Indian hedgehog homolog (Drosophila) HHG2 HHG-2 Indian hedgehog (Drosophila) homolog Indian hedgehog homolog indian hedgehog protein Indian hedgehog

Research Areas for Indian Hedgehog/Ihh

Find related products by research area and learn more about each of the different research areas below.

Stem Cell Signaling Pathway