ILT2/CD85j/LILRB1 Products

Description

LILRB1 is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.

Bioinformatics

Entrez	10859 Human
Uniprot	AAH15731 Human AAH15731.1 Human AAH27916 Human NP_006660 Human Q8NHL6 Human
Product By Gene ID	10859
Alternate Names	CD85 antigen-like family member J CD85j antigen CD85j CD85J Ig-like transcript 2 ILT-2 ILT2FLJ37515 Immunoglobulin-like transcript 2 leukocyte Ig-like receptor-1 Leukocyte immunoglobulin-like receptor 1 leukocyte immunoglobulin-like receptor subfamily B member 1 soluble isoform leukocyte immunoglobulin-like receptor subfamily B member 1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains) LIR1LIR-1MIR-7CD85MIR7CD85 antigen member 1 Monocyte/macrophage immunoglobulin-like receptor 7