HRD1 Products

Description

HRD1 is a ubiquitin ligase whose expression is induced by the unfolded protein response (UPR) following endoplasmic reticulum stress. Expression of HRD1 protects cells from apoptosis by inducing degradation of abnormally processed proteins that accumulate in the endoplasmic reticulum. HRD1 is expressed in many tissues, strongly expressed in brain, pancreas, liver, kidney and skeletal muscle. It has been reported that Synoviolin/Hrd1 (expressed in rheumatoid synovium) is a novel causative factor for arthropathy by triggering synovial cell outgrowth through its anti-apoptotic effects. HRD1 contains one ring-type zinc finger.

Bioinformatics

Entrez	74126 Mouse 84447 Human
Uniprot	NM_032431 Human NM_172230 Human NP_079434 Human NP_115807 Human NP_757385 Human NP_757385.1 Human Q86TM6 Human Q8N6E8 Human Q96PK3 Human
Product By Gene ID	84447
Alternate Names	E3 ubiquitin-protein ligase synoviolin EC 6.3.2 HRD1EC 6.3.2.- KIAA1810Synovial apoptosis inhibitor 1 MGC40372 synovial apoptosis inhibitor 1, synoviolin

Research Areas for HRD1

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Cell Biology
Ubiquitin Proteasome Pathway

Related HRD1 Blog Posts

Check out the latest blog posts on HRD1.

OS9: Taking proteins to the ER finish line The OS9 protein is a lectin/glycoprotein that maintains endoplasmic reticulum (ER) quality control and ER-associated degradation (the so-called ERAD pathway) of newly synthesized proteins. It is essential for the recognition of terminally misfolded no...    Read more.

Read more HRD1 related blogs.