HLA DQB1 Products

Description

HLA-DQB1 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and it contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation.

Bioinformatics

Entrez	3119 Human
Uniprot	AAH12106 Human AAH12106.1 Human NP_002114 Human
Product By Gene ID	3119
Alternate Names	DC-1 alpha chain DC-alpha HLA class II histocompatibility antigen, DQ alpha 1 chain-like HLA-DCA MHC class II DQA1

Research Areas for HLA DQB1

Find related products by research area and learn more about each of the different research areas below.

Asthma
Diabetes Research
Immunology