Description
FZD4 is a Frizzled Receptor involved in mediating Wnt signaling. A splicing variant of frizzled-4, FZD4s, encodes a soluble-type positive regulator of the Wnt signaling pathway. Mutations in FZD4 are associated with retinal angiogenesis. FZD4 is widely expressed, particularly in heart, skeletal muscle, ovary, and fetal kidney. Transcripts have also been identified in liver, kidney, pancreas, spleen, and fetal lung, and in smaller amounts in placenta, adult lung, prostate, testis, colon, and fetal brain. FZD4 expression has not been reported in several cancer cell lines studied. ESTs have been isolated from adipose, adrenal, B-cell/lung/testis, bone marrow, brain, breast, colon, embryo, gallbladder, head/neck, heart, heart/melanocyte/uterus, kidney, liver, liver/spleen, lung, placenta, prostate, skeletal muscle, skin, and vessel libraries.
Bioinformatics
| Entrez |
Rat
Human
|
| Uniprot |
Human
Human
Human
Human
|
| Product By Gene ID |
8322 |
| Alternate Names |
- CD344 antigen
- CD344
- EVR1
- exudative vitreoretinopathy 1
- FEVR
- frizzled (Drosophila) homolog 4
- frizzled homolog 4 (Drosophila)
- frizzled-4
- Fz-4
- FZD4S
- FzE4
- GPCR
- hFz4
- MGC34390
- WNT receptor frizzled-4
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