Ferritin Heavy Chain Products

Description

Stores iron in a soluble. nontoxic. readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Ferritin is a ubiquitous and highly conserved protein which plays a major role in iron homeostasis by sequestering and storing iron in a non-toxic and soluble form. It forms a holoenzyme of ~450 kDa, consisting of 24 subunits of two types, H (heavy; 21 kDa) and L (light; 19 kDa), and is capable of storing up to 4,500 atoms of ferric iron. Depending on the tissue type and physiological status of the cell, the ratio of H to L subunits in ferritin can vary widely. Ferritin is found in the liver, spleen, kidney and heart, with smaller amounts being found in blood. Serum ferritin levels serve as an indicator of the amount of iron stored in the body. Serum ferritin is the most sensitive test for anaemia, and is also used as a marker for restless leg syndrome, hemochromatosis and porphyria. As ferritin is an acute-phase reactant, it is often elevated during infection. Defects in ferritin proteins are associated with several neurodegenerative diseases.

Bioinformatics

Entrez	2495 Human
Uniprot	NP_002023.2 Human P02794 Human
Product By Gene ID	2495
Alternate Names	apoferritin Cell proliferation-inducing gene 15 protein Ferritin H subunit ferritin heavy chain ferritin, heavy polypeptide 1 FHC FTHEC 1.16.3.1 FTHL6MGC104426 PIG15 placenta immunoregulatory factor PLIF proliferation-inducing protein 15

Research Areas for Ferritin Heavy Chain

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Lipid and Metabolism