Fc gamma RIIIB/CD16b Products

Description

CD16 (FcgRIII) is a 50-65 kDa glycoprotein serving as a low affinity IgG receptor. Human FcgRIII is expressed in two forms FcgRIII-A and -B. FcgRIII-A is a transmembrane protein of monocytes, macrophages, NK cells and a subset of T cells. It is associated with FceRI-g subunit and is responsible for antibody-dependent NK cell cytotoxicity. Mast cell FcgRIII-A is associated, moreover, with FceRI-b subunit. Besides IgG, FceRI-A can be triggered also by oligomeric IgE. FcgRIII-B is a GPI-linked monomeric receptor expressed on neutrophils and is involved in their activation and induction of a proadhesive phenotype.

Bioinformatics

Entrez	2215 Human
Uniprot	O75015 Human
Product By Gene ID	2215
Alternate Names	CD16 CD16b antigen CD16B CD16b Fc fragment of IgG, low affinity IIIb, receptor (CD16b) Fc fragment of IgG, low affinity IIIb, receptor for (CD16) FCG3 Fc-gamma receptor IIIb (CD 16) Fc-gamma RIII Fc-gamma RIIIb Fc-gamma RIII-beta FCGR3 FcR-10 fcR-10 fcRIII FcRIII FcRIIIb fcRIIIb IGFR3 IgG Fc receptor III-1 low affinity immunoglobulin gamma Fc region receptor III-B