Factor VIII Products

Description

Von Willebrand Factor (VWF) was previously known as Factor VIII related antigen. VWF is synthesized exclusively by endothelial cells and megakaryocytes, and stored in the intracellular granules or constitutively secreted into plasma. This glycoprotein functions as both an antihemophilic factor carrier and a platelet vessel wall mediator in the blood coagulation system. Important in the maintenance of homeostasis, it participates in platelet vessel wall interactions by forming a noncovalent complex with coagulation factor VIII at the site of vascular injury. The Von Willebrand factor has functional binding domains to platelet glycoprotein Ib, glycoprotein IIb/IIIa, collagen and heparin. Mutations in this gene or deficiencies in this protein result in Von Willebrand's disease. VWD is characterized by frequent bleeding (gingival, minor skin quantitative lacerations, menorrhagia, etc.).

Bioinformatics

Entrez	14069 Mouse 2157 Human
Uniprot	NM_019863 Human NP_000123 Human NP_063916.1 Human P00451 Human Q06194 Mouse
Product By Gene ID	2157
Alternate Names	AHF Antihemophilic factor coagulation factor VIII, procoagulant component coagulation factor VIIIc DXS1253E F8Ccoagulation factor VIII factor VIII F8B FVIII HEMAF8B Procoagulant component

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Factor VIII - a key factor in the clotting process Hemostasis, or blood clotting, follows tissue injury and involves the deployment of essential plasma procoagulants (such as prothrombin, and Factors X, IX, V, and VIII) that trigger the blood coagulation cascade. This cascade leads to the formation...    Read more.

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