Exostosin-like 3/EXTL3 Products

Description

EXTL3, also referred to as Exostosin-like 3, is a glycosyltransferase and a critical player in the control of keratinocyte proliferation and differentiation via its interaction with REG3A. EXTL3 is 919 amino acids in length and approximately 105kDa. Current research surrounding EXTL3 has shown a possible link with several diseases and disorders such as colorectal cancer, HIV, hepatitis, gonorrhea, syphilis, exostosis, pancreatitis and rheumatic aortic stenosis. EXTL3 has also been shown to interact with Fyn, Crk, Phospholipase C gamma 1, PI 3 Kinase p85 alpha, and PEPP2 in pathways such as Glycosaminoglycan biosynthesis, heparan sulfate biosynthesis, the activation of Chaperones by IRE1alpha, and protein metabolism pathways.

Bioinformatics

Entrez	2137 Human
Uniprot	NM_001440 Human NP_001431.1 Human O43909 Human
Product By Gene ID	2137
Alternate Names	botv DKFZp686C2342 EC 2.4.1.223 exostoses (multiple)-like 3 exostosin-like 3 EXTL1L EXTR1BOTV EXT-related protein 1 Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase Hereditary multiple exostoses gene isolog KIAA0519 Multiple exostosis-like protein 3 Putative tumor suppressor protein EXTL3 reg receptor REG REGR RPR

Research Areas for Exostosin-like 3/EXTL3

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Stem Cell Markers