ERp57/PDIA3 Products

Description

ERp57, also known as Glucose Regulated Protein 58 (Grp58), Hormone-Induced Protein-70 (HIP-70) and microsomal Carnitine Palmitoyltransferase, is a member of the protein disulfide isomerase family, containing two canonical CXHC tetrapeptide active site motifs (1-5). It has quite a few diverse roles. It functions as an accessory oxidoreductase involved in disulfide bond formation. In the ER, ERp57 interacts with membrane bound calnexin and soluble calreticulin (lectin chaperones) via their praline rich P-domain arms. Lectin chaperones bind nascent non-native glycoproteins, and position ERp57 to act upon the immature or misfolded glycoproteins that possess mono-glucosylated side chains. ERp57 deletion impairs posttranslational phases of influenza hema-glutinin folding, and causes accelerated release of MHC-I molecules, resulting in the coupling of sub-optimal peptides and reduced expression and stability on the cell surface (6). ERp57 also contains two thioredoxin active-site sequences, CGHC and an estrogen-binding domain. ERp57 is induced by both estrogen and leuteinizing-hormone-releasing hormone in the hippocampus (7).

Bioinformatics

Entrez	14827 Mouse 2923 Human 29468 Rat
Uniprot	AAH14433 Human NM_005313 Human NP_005304. Human NP_005304.3 Human P30101 Human
Product By Gene ID	2923
Alternate Names	Disulfide isomerase ER-60 EC 5.3.4.1 endoplasmic reticulum P58 Endoplasmic reticulum resident protein 57 Endoplasmic reticulum resident protein 60 ER protein 60 ER60 ERP57 ERp5758 kDa glucose-regulated protein ERP60 ERp6058 kDa microsomal protein ERp61 glucose regulated protein, 58kDa GRP57 GRP58ER protein 57 HsT17083 P58 p58 phospholipase C-alpha PI-PLC protein disulfide isomerase family A, member 3 protein disulfide isomerase-associated 3 protein disulfide-isomerase A3

Research Areas for ERp57/PDIA3

Find related products by research area and learn more about each of the different research areas below.

Cellular Markers
ER Markers
Membrane Trafficking and Chaperones