epithelial Sodium Channel beta Products

Description

SCNN1B is a subunit of the epithelial sodium channel, ENaC. ENac has high sodium selectivity, low conductance, and amiloride sensitivity. The functional channel of ENaC is composed of at least 3 subunits, alpha (SCNN1A), beta (SCNN1B), and gamma (SCNN1G). The 3 subunits show sequence similarities to one another, indicating descent from a common ancestral gene. Each encodes a protein containing 2 transmembrane domains, with intracellular amino and carboxyl termini. ENaC in the kidney, lung and colon plays an essential role in trans- epithelial sodium and fluid balance. ENaC also mediates aldosterone-dependent sodium re-uptake in the distal nephron of the kidney, thus regulating blood pressure. Mutations in beta or gamma subunit of the epithelial sodium channel (ENaC) have been found to cause a hereditary form of human hypertension, Liddle syndrome.

Bioinformatics

Entrez	20277 Mouse 24767 Rat 6338 Human
Uniprot	AAH36352 Human AAH36352.2 Human NM_000336 Human P37090 Rat P51168 Human
Product By Gene ID	6338
Alternate Names	amiloride-sensitive sodium channel subunit beta 1 amiloride-sensitive sodium channel subunit beta BESC1 Beta-ENaC beta-ENaC beta-NaCH Beta-NaCH ENaCb ENaCB ENaCbeta Epithelial Na(+) channel subunit beta epithelial sodium channel beta-2 subunit epithelial sodium channel beta-3 subunit nasal epithelial sodium channel beta subunit Nonvoltage-gated sodium channel 1 subunit beta SCNEB sodium channel, nonvoltage-gated 1, beta

Research Areas for epithelial Sodium Channel beta

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Phospho-Specific