epithelial Sodium Channel alpha Products

Description

Epithelial Sodium Channel alpha (SCNN1A) is a subunit of the epithelial sodium channel (ENaC). ENac has high sodium selectivity, low conductance, and amiloride sensitivity. The functional channel of ENaC is composed of at least 3 subunits, alpha (SCNN1A), beta (SCNN1B), and gamma (SCNN1G). The 3 subunits show sequence similarities to one another, indicating descent from a common ancestral gene. Each encodes a protein containing 2 transmembrane domains, with intracellular amino and carboxyl termini. The alpha subunit supports sodium conductance when expressed alone; the beta and gamma subunits do not support sodium conductance by themselves, but greatly augment the channel activity when expressed in conjunction with the alpha subunit. ENaC in the kidney, lung and colon plays an essential role in trans- epithelial sodium and fluid balance. ENaC also mediates aldosterone-dependent sodium re-uptake in the distal nephron of the kidney, thus regulating blood pressure. Gain-of-function mutations in beta- or gamma-ENaC can cause severe arterial hypertension (Liddel's syndrome) and loss-of-function mutations in alpha- or beta-ENaC causes pseudohypoaldosteronism (PHA-1).

Bioinformatics

Entrez	20276 Mouse 25122 Rat 6337 Human
Uniprot	NP_001029 Human NP_001029.1 Human P37088 Human P37088#P37088-3 Human
Product By Gene ID	6337
Alternate Names	alpha ENaC-2 Alpha-ENaC alpha-ENaC Alpha-NaCH alpha-NaCH amiloride-sensitive epithelial sodium channel alpha subunit amiloride-sensitive sodium channel subunit alpha 2 amiloride-sensitive sodium channel subunit alpha BESC2 ENaCa ENaCA ENaCalpha Epithelial Na(+) channel subunit alpha FLJ21883 nasal epithelial sodium channel alpha subunit Nonvoltage-gated sodium channel 1 subunit alpha SCNEA SCNN1 sodium channel, nonvoltage-gated 1 alpha