ECH1 Products

Description

ECH1 encodes a member of the hydratase/isomerase superfamily. The gene product shows high sequence similarity to enoyl-coenzyme A (CoA) hydratases of several species, particularly within a conserved domain characteristic of these proteins. The encoded protein, which contains a C-terminal peroxisomal targeting sequence, localizes to the peroxisome. The rat ortholog, which localizes to the matrix of both the peroxisome and mitochondria, can isomerize 3-trans,5-cis-dienoyl-CoA to 2-trans,4-trans-dienoyl-CoA, indicating that it is a delta3,5-delta2,4-dienoyl-CoA isomerase. This enzyme functions in the auxiliary step of the fatty acid beta-oxidation pathway. Expression of the rat gene is induced by peroxisome proliferators.

Bioinformatics

Entrez	1891 Human
Uniprot	AAH17408 Human NM_001398 Human NP_001389 Human NP_001389.2 Human Q13011 Human
Product By Gene ID	1891
Alternate Names	delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial delta3,5-delta2,4-dienoyl-CoA isomerase dienoyl-CoA isomerase EC 5.3.3.- enoyl CoA hydratase 1, peroxisomal enoyl Coenzyme A hydratase 1, peroxisomal HPXEL peroxisomal enoyl-CoA hydratase 1

Research Areas for ECH1

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Lipid and Metabolism