EBP Products

Description

The protein encoded by the EBP gene is an integral membrane protein of the endoplasmic reticulum. It is a high affinity binding protein for the antiischemic phenylalkylamine Ca2+ antagonist (3H)emopamil and the photoaffinity label (3H)azidopamil. It is similar to sigma receptors and may be a member of a superfamily of high affinity drug-binding proteins in the endoplasmic reticulum of different tissues. This protein shares structural features with bacterial and eukaryontic drug transporting proteins. It has four putative transmembrane segments and contains two conserved glutamate residues which may be involved in the transport of cationic amphiphilics. Another prominent feature of this protein is its high content of aromatic amino acid residues (>23%) in its transmembrane segments. These aromatic amino acid residues have been suggested to be involved in the drug transport by the P-glycoprotein. Mutations in this gene cause Chondrodysplasia punctata 2 (CDPX2; also known as Conradi-Hunermann syndrome). (provided by RefSeq)

Bioinformatics

Entrez	10682 Human
Uniprot	NM_006579 Human Q15125 Human
Product By Gene ID	10682
Alternate Names	3-beta-hydroxysteroid-Delta(8) CDPX2 Cholestenol Delta-isomerase CPX3-beta-hydroxysteroid-delta-8 CPXDX-linked dominant (Happle syndrome) D8-D7 sterol isomerase Delta(7)-isomerase Delta(8)-Delta(7) sterol isomerase delta-7-isomerase EC 5.3.3.5 emopamil binding protein (sterol isomerase) Emopamil-binding protein sterol 8-isomerase