Species: Hu, Rt
Applications: WB, IHC
Host: Mouse Monoclonal
Species: Hu
Applications: WB, ELISA, ICC/IF
Host: Rabbit Polyclonal
Species: Hu, Mu, Rt
Applications: WB
Host: Sheep Polyclonal
Species: Hu
Applications: WB, ELISA, MA, AP, Enzyme Activity
Species: Hu
Applications: AC
Species: Hu
Applications: AC
Description
DYRK2, or dual specificity tyrosine-phosphorylation-regulated kinase 2, has a role in the regulation of cellular growth and/or development. In response to DNA damage, DYRK2 regulates p53 phosphorylation on Ser-46 to induce apoptosis. DYRK2 has been proposed to inactivate GYS1 by phosphorylation at Ser-641, and potentially a second phosphorylation site, thus regulating glycogen synthesis. DYRK2 also phosphorylates EIF2B5 at Ser-544, enabling its subsequent phosphorylation and inhibition by GSK3, and may play a more general role in the priming of GSK3 substrates.
Bioinformatics
| Entrez |
Rat
Mouse
Human
|
| Uniprot |
Human
Human
Human
Human
|
| Product By Gene ID |
8445 |
| Alternate Names |
- dual specificity tyrosine-phosphorylation-regulated kinase 2
- dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
- EC 2.7.12
- EC 2.7.12.1
- FLJ21217
- FLJ21365
|
Research Areas for DYRK2
Find related products by research area and learn more about each of the different research areas below.
ApoptosisProtein Kinase
![Western Blot DYRK2 Antibody (599542) [Unconjugated]](http://images.novusbio.com/fullsize2/DYRK2_MAB5408_Western_Blot_9913.jpg)
