DNMT1 Products

Description

DNA (cytosine-5)-methyltransferase 1 (DNMT1) plays a role in the regulation of tissue-specific cytosine residue methylation patterns that are established during development. Spec ifically, DNMT-1 interacts with Histone deacetylases and other methyltransferases to preferentially methylate hemimethylated DNA in coordination with the methylation of histones.

Improper methylation patterns have been linked to certain human tumors and developmental abnormalities. DNMT1 antibodies are useful tools for DNA methlyation research and studies on certian cancer.

Bioinformatics

Entrez	13433 Mouse 1786 Human 84350 Rat
Uniprot	NP_001370 Human NP_001370.1 Human P26358 (human) Human P26358 Human
Product By Gene ID	1786
Alternate Names	AIM CXXC9CXXC finger protein 9 CXXC-type zinc finger protein 9 DNA (cytosine-5-)-methyltransferase 1 DNA (cytosine-5)-methyltransferase 1 DNA methyltransferase 1 DNA methyltransferase HsaI DNA MTase HsaI DNMT Dnmt1 EC 2.1.1.37 FLJ16293 M.HsaI m.HsaI MCMTMGC104992

Research Areas for DNMT1

Find related products by research area and learn more about each of the different research areas below.

Angiogenesis
Cancer
Chromatin Modifiers
Chromatin Research
Core ESC-Like Genes
DNA Methyltransferases
Epigenetics
Phospho-Specific
Stem Cell Markers
Transcription Factors and Regulators

Related DNMT1 Blog Posts

Check out the latest blog posts on DNMT1.

The role of DNMT3A in development Epigenetics is the study of heritable change in gene activity despite alteration of the hosts DNA sequence.  Change in gene activity done independently of the DNA sequence is achieved by way of histone and DNA methylation.  Gene silencing in DNA ...    Read more.

The role of DNMT3B in the co-incidence of methyltransferase and tumor suppressor expression in malignancies Epigenetics is the process of heritable change in gene activity despite alteration of the hosts DNA sequence, essentially causing a change in a phenotype without a change in the genotype of a host. To change the gene sequence without interfering w...    Read more.

DNMT's: An Overview of 3 DNA Methyltransferases DNA methyltransferases catalyze the transfer of the methyl group from S-andenosyl methionine (SAM) to DNA. Such methylation has wide ranging function in the cell, including organismal development and cell differentiation. In cancer, abnormal hypermeth...    Read more.

PCNA Antibodies: Marking Cell Proliferation & DNA Replication Proliferating Cell Nuclear Antigen (PCNA), also known as the polymerase delta auxiliary protein, is a nuclear protein essential for DNA replication as well as DNA excision and mismatch repair pathways. It has a large role in cell cycle regulation and ...    Read more.

Controlling Epigenetic Signaling with Dnmt1 and Dnmt3b Dnmt1 belongs to the C5-methyltransferase family that repairs cytosines in dsDNA using a nucleophilic attack mechanism. Dnmt1 is the most abundant mammalian DNA methyltransferase. It is the key methylation maintenance enzyme for both DNA replication/r...    Read more.

Read more DNMT1 related blogs.