COP Products

Description

Caspase inhibitor. Acts as a regulator of procaspase-1/CASP1 activation implicated in the regulation of theproteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release ofIL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro-inflammatory cytokineresponse. Also able to inhibit CASP1-mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, andstaurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspasesCASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2

Bioinformatics

Entrez	114769 Human
Uniprot	NM_052889 Human NP_001017534 Human NP_443121 Human NP_443121.1 Human
Product By Gene ID	114769
Alternate Names	CARD only domain-containing protein 1 CARD only protein caspase recruitment domain family, member 16 Caspase-1 inhibitor COP COP1caspase-1 dominant-negative inhibitor pseudo-ICE COPcaspase recruitment domain-containing protein 16 EC 3.4.22.36 Pseudo interleukin-1 beta converting enzyme pseudo interleukin-1beta converting enzyme PSEUDO-ICE Pseudo-ICE

Research Areas for COP

Find related products by research area and learn more about each of the different research areas below.

Apoptosis