Connexin 26/GJB2 Products

Description

Connexin-26 / GJB2 is a gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexins, through which materials of low molecular weight diffuse from one cell to a neighboring cell. Each connexin is composed of a hexamer of connexin proteins. Connexins are a multi-gene family of highly related proteins. At least a dozen distinct connexin genes have been identified and many are expressed in a tissue-specific manner. Two distinct lineages, class I (beta) and class II (alpha), have been identified in mammals. Connexin-26 belongs to the class 1 (beta) group of connexins. Mutations in Connexin-26 are associated with genetically derived hearing impairments, including autosomal recessive non syndromic deafness.

Bioinformatics

Entrez	14619 Mouse 2706 Human 394266 Rat
Uniprot	AAH17048 Human NP_003995 Human NP_003995.2 Human P29033 Human
Product By Gene ID	2706
Alternate Names	beta 2, 26kD (connexin 26) Cx26 CX26DFNA3 DFNA3A DFNB1 gap junction protein, beta 2, 26kDa (connexin 26) gap junction protein, beta 2, 26kDa NSRD1

Research Areas for Connexin 26/GJB2

Find related products by research area and learn more about each of the different research areas below.

Neuroscience
Sensory Systems