Claudin-18 Products

Description

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified.

Bioinformatics

Entrez	51208 Human
Uniprot	NP_057453 Human NP_057453.1 Human P56856 Human
Product By Gene ID	51208
Alternate Names	claudin 18 SFTA5 SFTPJ surfactant associated 5 surfactant associated protein J surfactant, pulmonary associated protein J