cIAP-1/HIAP-2 Products

Description

cIAP1 (HIAP2, MIHB) is a member of the family of inhibitor of apoptosis proteins (IAP). IAPs suppress mitochondria-dependent and -independent apoptosis by binding to and inhibiting caspases through their BIR domains (reviewed in Liston et al, 2003; Wright and Duckett, 2005). Resistance towards apoptosis is a hallmark of cancer cells, and overexpression of IAPs can contribute to the development of cancer though inhibiting apoptosis. In addition to at least one BIR domain, some IAP members also have a RING-type finger motif at their carboxyl-terminal. The RING finger domain of several IAPs, including cIAP2, have E3 ubiquitin ligase activity and target the degradation of Smac/DIABLO through ubqiuitination. Smac/DIABLO is a death inducer and functions by inhibiting IAP-caspase interactions, thereby promoting apoptosis. Degradation of cell death inducers like Smac/DIABLO is thought to be a conserved mechanism by which IAPs enhance their anti-apoptotic activity, thereby promoting cell survival. The IAPs, including cIAP1, have widespread tissue protein expression, with expression levels and subcellular localization patterns differing depending on the cell lineage (see Vischioni et al. 2005 for a comprehensive study). This antibody recognizes cIAP1, human cIAP1 is a 618 amino acid protein.

Bioinformatics

Entrez	11797 Mouse 329 Human
Uniprot	NP_001157 Human NP_001157.1 Human Q13490 Human
Product By Gene ID	329
Alternate Names	API1Hiap-2 apoptosis inhibitor 1 baculoviral IAP repeat containing 2 baculoviral IAP repeat-containing 2 baculoviral IAP repeat-containing protein 2 cIAP1 c-IAP1 C-IAP1 hIAP2 hIAP-2 IAP homolog B IAP2 IAP-2 Inhibitor of apoptosis protein 2 MIHBHIAP2 NFR2-TRAF signalling complex protein RING finger protein 48 RNF48hiap-2 TNFR2-TRAF-signaling complex protein 2

Research Areas for cIAP-1/HIAP-2

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Apoptosis

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cIAP1 - An apoptotic regulator with implications in drug resistant cancers Cellular inhibitor of apoptosis protein-1 (cIAP-1) is an anti-apoptotic protein that is able to bind to caspases and inhibit their activity. Additionally cIAP-1 contains a RING domain with E3 ubiquitin ligase activity that is able to mediate the r...    Read more.

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