cGK1/PRKG1 Products

Description

cGK1/PRKG1, also known as cGMP-dependent protein kinase 1, has two isoforms that are produced by alternative splicing. Isoform Alpha (CGK1-alpha) is 671 amino acids long and 76 kDa. Isoform Beta (CGK1-beta) is 686 amino acids long and approximately 78 kDa. PRKG1 is a Serine/threonine protein kinase that is expressed in placenta and lung. cGK1/PRKG1 is an important player in the Nitric Oxide/cGMP Signaling Pathway; the binding of GMP activates PRKG1, which in turn phosphorylates Serine residues and Threonine residues on various cell proteins, including proteins that regulate calcium levels, smooth muscle contraction, platelet adhesion, circadian rhythm and more. Current research on PRKG1 is being conducted in relation to several diseases and disorders including cystic fibrosis, lymphoma, non-small cell lung carcinoma, Wiskott-Aldrich syndrome, Waterhouse-Friderichsen syndrome and myoglobinuria. PRKG1 has also been shown to have interactions with SMAD4, BMPR2, GKAP1, Natriuretic Peptide Receptor A and TFII-I in pathways such as Gap Junction signaling, eNOS signaling and EDNRB signaling.

Bioinformatics

Entrez	5592 Human
Uniprot	AAH62688.1 Human ABQ59040 Human NM_006258 Human NP_006249 Human P14619 Human
Product By Gene ID	5592
Alternate Names	AAT8 cGK 1 cGK cGK1 CGKI cGKI cGKI-alpha cGKI-BETA cGMP-dependent protein kinase I DKFZp686K042 EC 2.7.11 EC 2.7.11.12 FLJ36117 PKG PKG1 PRKG1B PRKG1BMGC71944 PRKGR1A PRKGR1B PRKGR1BcGMP-dependent, regulatory, type I, beta protein kinase cGMP-dependent 1 protein kinase, cGMP-dependent, type I

Research Areas for cGK1/PRKG1

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Protein Kinase