Species: Hu, Mu, Rt
Applications: WB, Flow, ICC/IF, IHC
Host: Rabbit Polyclonal
Species: Hu, Mu, Rt
Applications: WB, Flow, ICC/IF, IHC
Host: Rabbit Polyclonal
Species: Mu
Applications: AC
Description
CD11b, also known as Integrin alpha M, is one half of the heterodimeric integrin alpha-M beta-2 molecule. This protein mediates inflammation by regulating leukocyte adhesion and migration and has been implicated in several immune processes such as phagocytosis, cell-mediated cytotoxicity, chemotaxis and cellular activation. CD11b is expressed on the surface of many leukocytes involved in the innate immune system, including monocytes, granulocytes, macrophages, and natural killer cells. Mutations in the CD11b protein have been assosicated with the autoimmune disease lupus, and CD11b antibodies are therefore commonly in immunology studies.
CD11c, also known as Integrin alpha X, is a type I transmembrane protein found at high levels on most human dendritic cells, but also on monocytes, macrophages, neutrophils, and some B cells that induces cellular activation and helps trigger neutrophil respiratory burst; expressed in hairy cell leukemias, acute nonlymphocytic leukemias, and some B-cell chronic lymphocytic leukemias.
Bioinformatics
| Entrez |
Mouse
Human
|
| Uniprot |
Mouse
Human
|
| Product By Gene ID |
3684 |
| Alternate Names |
- antigen CD11b (p170)
- CD11 antigen-like family member B
- CD11b antigen
- CD11b
- CD11Bintegrin, alpha M (complement component receptor 3, alpha; also known as CD11b(p170), macrophage antigen alpha polypeptide)
- Cell surface glycoprotein MAC-1 subunit alpha
- CR-3 alpha chain
- CR3AMGC117044
- integrin alpha-M
- integrin, alpha M (complement component 3 receptor 3 subunit)
- Leukocyte adhesion receptor MO1
- MAC-1
- MAC1A
- macrophage antigen alpha polypeptide
- MO1A
- neutrophil adherence receptor alpha-M subunit
- Neutrophil adherence receptor
- SLEB6
|
