CBX4 Products

Description

PC2 is the human homolog of the Drosophila 'Polycomb' (Pc) protein which has been identified as a gene family member associated with a cellular memory system that is responsible for the inheritance of gene activity by progeny cells. The human Pc homolog gene is more closely related to a Xenopus Pc homolog, XPc, than to a previously described human Pc homolog, CBX2 (hPc1). However, the hPc2 and CBX2/hPc1 proteins are shown to colocalize in interphase nuclei of human U-2 OS osteosarcoma cells, suggesting that the proteins are part of a common protein complex. The human protein is believed to function as a repressor of proto-oncogene activity and that interference with hPc2 function can lead to derepression of proto-oncogene transcription and subsequently to cellular transformation. Other reports describe PC2 as a protein that has SUMO E3 activity for the corepressors CtBP and CtBP2.

Bioinformatics

Entrez	8535 Human
Uniprot	AAH14967.1 Human NP_003646 Human O00257 Human
Product By Gene ID	8535
Alternate Names	chromobox homolog 4 (Drosophila Pc class) chromobox homolog 4 Chromobox protein homolog 4 Drosophila) E3 SUMO-protein ligase CBX4 hPc2 hPC2 NS5ATP1-binding protein 16 Pc class 2 homolog Pc2 PC2 Polycomb 2 homolog

Research Areas for CBX4

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Apoptosis