Caveolin-2 Products

Description

Caveolae are cholesterol/sphingolipid-rich microdomains of the plasma membrane that have been implicated in signal transduction and vesicular trafficking. Caveolins are a family of caveolae-associated integral membrane proteins (1). Caveolin, a 21- to 24-kDa integral membrane protein, is a principal component of caveolae membranes. Caveolin interacts directly with heterotrimeric guanine nucleotide binding proteins (G proteins) and can functionally regulate their activity. Caveolins 1 and 2 are similar in most respects, however, caveolin-1 and caveolin-2 differ in their functional interactions with heterotrimeric G proteins, possibly explaining why caveolin-1 and -2 are coexpressed within a single cell (2). Caveolin-2 is up-regulated in response to the mechanical injury of differentiated PC12 cells; up-regulation of caveolin-2 under these conditions is strictly dependent on continued treatment with NGF. Robust expression of caveolin-1 and -2 is also observed along the entire cell surface of DRG neurons, including high levels on growth cones. These findings demonstrate that neuronal cells express caveolins (1).

Bioinformatics

Entrez	858 Human
Uniprot	NM_001233 Human NM_198212 Human NP_001224.1 Human
Product By Gene ID	858
Alternate Names	CAV caveolae protein, 20-kD caveolin 2 isoform a and b caveolin 2 caveolin-2 MGC12294

Research Areas for Caveolin-2

Find related products by research area and learn more about each of the different research areas below.

Caveolae Markers
Membrane Trafficking and Chaperones
Neuroscience
Phospho-Specific