Calpastatin Products

Description

The calpain system has been detected in every vertebrate tissue examined, and has been suggested to play a regulatory role in cellular protein metabolism. This regulatory role may have important implications in platelet aggregation and pathologies associated with altered calcium homeostasis and protein metabolism such as ischemic cell injury and degenerative diseases. Inhibitors of calpain have been shown to block dexamethasone and low-level irradiation induced apoptosis in thymocytes suggesting that calpain has a regulatory or mechanistic role in apoptotic cell death.Calpastatin, a specific endogenous inhibitor of calpain, has a predicted molecular weight of ~77 kDa and an internal repeat of four homologous domains which allow it to inhibit multiple calpain molecules simultaneously. It functions by binding to calpain when calpain binds calcium. When Calpastatin is subjected to proteolytic digestion, fragments of calpastatin as small as 15 kDa still retain inhibitory activity.

Bioinformatics

Entrez	25403 Rat 831 Human
Uniprot	AAH13579 Human AAH13579.1 Human NM_001750 Human NP_775083.1 Human P20810 Human P20811 Bovine
Product By Gene ID	831
Alternate Names	BS-17 Calpain inhibitor calpastatin MGC9402 Sperm BS-17 component

Research Areas for Calpastatin

Find related products by research area and learn more about each of the different research areas below.

Hypoxia
Neuroscience