Species: Mu
Applications: WB, ICC/IF, IHC, IP, NULL
Host: Rabbit Polyclonal
Species: Hu, Mu, Rt
Applications: WB
Host: Rabbit Polyclonal
Species: Mu
Applications: WB, ICC/IF, IHC, IP
Host: Rabbit Polyclonal
Description
Function: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. R-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by nickel, and partially by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to dihydropyridines (DHP), omega-conotoxin-GVIA (omega-CTx-GVIA), and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels contaning alpha-1E subunit could be involved in the modulation of firing patterns of neurons which is important for information processing.; Subcellular location: Membrane; Multi-pass membrane protein.; Tissue specificity: Expressed in neuronal tissues and in kidney.
Bioinformatics
| Entrez |
Mouse
Rat
Human
|
| Uniprot |
Human
Human
|
| Product By Gene ID |
777 |
| Alternate Names |
- Brain calcium channel II
- CACH6calcium channel, R type, alpha-1 polypeptide
- CACNL1A6calcium channel, voltage-dependent, alpha 1E subunit
- calcium channel, voltage-dependent, R type, alpha 1E subunit
- Cav2.3
- L type, alpha-1 polypeptide
- L type, alpha-1 polypeptide, isoform 6
- voltage-dependent calcium channel alpha 1E subunit
- voltage-dependent R-type calcium channel subunit alpha-1E
- voltage-gated calcium channel alpha 1E subunit
- Voltage-gated calcium channel subunit alpha Cav2.3
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